中藥劑量與毒性間之關係探討及中藥肝腎毒性相關研究

陳玉芳
中國醫藥大學
依據衛生署中醫藥委員會之推展中藥用藥安全及本年度之研究重點，本計畫選擇雷公藤進行劑量與毒性相關係之研究及肝腎毒性之研究，包括血液學檢查、臨床血液生化檢查、尿液檢查、解剖、病理組織學檢查；其次，進行肝腎毒性之研究，包括生化值檢查、病理檢查、免疫組織化學染色，以了解雷公藤之劑量與毒性及其對肝腎之影響。
關鍵字：雷公藤；劑量與毒性；肝腎毒性

Investigation of the relationship between dosage and toxicity and the hepatoxicity and renal toxicity induced by Chinese herb

Yuh-Fung Chen
China medical university
According to the policy of the use safety of Chinese Herbal drug by CCMP and the research focuses of year 2009, the relationship between doss and toxicity and liver and kidney toxicity of Tripterygium wilfordii Hook will be evaluated in this study. The blood routine check, clinical biochemistry check, urine check, anamtomy and pathological histological check will be primarily studied. Biochemical data check, pathological check, immunohistological staining will be used to evaluate the relationship between dose and toxicity and the hepatotoxicity, renal toxicity induced by Tripterygium wilfordii Hook.
關鍵字：Tripterygium wilfordii Hook；dose and toxicity；liver and kidney toxicity