桂枝苻苓丸、四磨飲、瀉青丸漢四逆散對實驗性大鼠急性肝損傷之影想

林國瑞
私立中國醫
肝病是中國人常見的疾病，其相關病變久為台灣地區十大死亡原因之一。現代醫藥對其並無令人滿意之對策，有待改進。而中醫對此疾病之治療有悠久的歷史與豐富臨床經驗，並且有其獨特多元化的學理思路及相當的療效，給肝病患者提供了很大的希望。
為究明中醫藥之療效與作用機轉，並探討中醫學理之實質，而進行本實驗。本計畫擬以四種中醫方劑 : 四磨飲 ( 理氣 ) 、 桂枝茯苓丸 ( 理血 ) 、 瀉青丸 ( 瀉火 ) 和四逆散( 和解 ) 之水抽出物進行各種保肝模型之試驗。 包括 : 四氯化碳 ( CCl4 ) 、乙醇 ( Alcohol ) 和醋氨酚 ( Acetaminophen )肝毒性物質誘發各種不同急性肝損傷，以期對中醫藥做深入之探討，開發肝病醫療新資源。
第二年將該傳統方劑對實驗性慢性肝損傷(纖維化、肝硬化)等逕行作用探討，以四氯化碳（CCl4）誘發肝臟纖維化之模式，進行評估四磨飲、桂枝茯苓丸、瀉青丸、四逆散等方要對此等慢性肝損之療效。
第三年擬運用第一、第二年之成果基礎，將此方劑應用於相關病患進行臨床評估
及一系列之機轉探討。其中包括對Lipid Peroxidation之影響，Free Radical之清除、
SOD之含量、DNA肝損傷、Cytochrome P450 enzyme system之活性…….等等作深入研究。
關鍵字：肝病，中醫，中醫方劑，慢性肝損傷。

Effect of Chinese Materia: Syh-Mo-Yiin, Guizhi-Fuling,-Wan, Shieh-Qing-Wan and Syh-Nih-\sann on Experimental Acute Liver Damage in Rodents

Lin Kuo-Juei
China Medical Collage
As an endemic area of liver diseases in China, the hazard became one of the Ten Leading
Causes of Death in Taiwan Area of years. Until recently, it has been accepted that 
pharmacological treatment of liver disease qas diffict. Treatment of patients with liver diseases
still remains to be improved. However traditional Chinese Medicine (TCM), with diverse and
unique thinking-process, developed through clinical practices and proved to be useful for 
centuries in the remedy of liver trouble. Interest in TCM on hepatic medications has increased 
widely in recent years.
Acute liver damages induced by ethanol and acetaminophen in rats were conducted to elucidate the hepatoprotective effects of TCM and study the essence of it. Water extracts of four prescriptions of Chinese Materia Medical: Syn-Mo-Yiin (SMY), Guizhi-Fuling-Wan(GFW), Shieh-Qing-Wan(SQW), and Syh-Nih-Sann(SNS), used in this study, were medicinal herbs and prepared according to different factions
關鍵字：Disease of the Liver, Traditional Chinese Medicine, Chinese Material, Acute Liver Damage