中醫方劑（GLY）對鼻咽癌以放射線治療後所引起副作用之療效評估

林宜信
林口長庚紀
放射線是公認治療鼻咽癌的首選有效方法，病人卻得付出較嚴重急性輻射傷害的代價。口腔粘膜發炎(Mucositis)是鼻咽癌接受放射線治療後最常見的併發症。其影響患者平日之生活品質，尤其是進食吞嚥及說話品質很大；其影響甚至可長達數十年，且無積極有效方法的療效報告。
本研究計劃全程二年(89.11.1~90.12.31)預定納入180個病案，納入對象為罹患鼻咽癌經放射線治療結束後一年以上之患者，預計有效案例至少150個。本研究設計分為三組：D1係為現行臨床標準原典劑量組； D2為現行臨床標準原典劑量加倍組及D3(Plaecbo)組。本研究旨在瞭解中醫方劑（GLY）能否改善放射線治療鼻咽癌後引起之急性副作用，以及在D1，D2及Plaecbo三組間之差異。
第一年(89.1.1~89.12.31)已有120位病患納入此試驗，由於本研究為期兩年，並為隨機雙盲之臨床試驗，故不宜中途解碼；目前繼續在服藥中的病患計100位，研究繼續進行中。估計以每月可納入10-15個新案例之進度，研究應可如期順利完成，屆時將進行完整而嚴謹之統計。
關鍵字：鼻咽癌、Mucositis、放射線、中醫藥、方劑

『Mucositis and dry mouth due to NPC radiotherapy treated by Chinese herb Gan-Lu-Yin』

Lin, I Hsin
Chang Gung Memorial Hospital
Nasopharyngeal carcinoma(NPC) is one of the ten leading cancer in Taiwan, Currently, radiotherapy is the best method to treat NPC. But it may induce some acute or late complications such as mucositis or dry mouth which may bother patients and further interrupt the course of treatment. Unfortunately, there is no better treatment to relieve the complications of radiotherapy.
Our previous studies (CCMP87-RD-038&CCMP88-RD-009) have indicated that Chinese herb may have effects for complication of NPC radiotheropy. In the present randomized and double blind study(2000-1-1~2001-12-31), we plan to treat complications of post-radiotherapy NPC patients with Chinese herb medication (GLY Formulation), the complications were including mucositis and dry mouth due to radiotherapy. One hundred patients including 75effective cases have been studied in the first year. Total 180 NPC patients including 150 cases of this progran will be finished within 2 years period. The including criteria are NPC patie
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