蛇床子萃取物陰道栓劑之製備暨作為抗陰道滴蟲之評估(2-2)

詹道明
私立高雄醫
在去年的計劃中，曾成功的自蛇床子中藥材中分離得到蛇床子素。初步實驗證明蛇床子素對抗陰道滴蟲具有活性。

本計劃擬將蛇床子萃取物(浸膏)配合水溶性及非水溶性基劑製備陰道用栓劑。探討所製得栓劑之物理性質及主成分蛇床子素自各栓劑中釋出之情形。並且以庫爾特粒子計數儀及流式細胞分析儀，評估釋出主成分對抗陰道滴蟲之效益。

關鍵字：蛇床子、抗陰道滴蟲、陰道用栓劑、蛇床子素

A Study on the preparation and evaluation of Cnidii Fructus extract for Anti-trichomonas Vaginalis activity: a second project

Thau-Ming Cham
Kaohsiung Medical College
During the previous study，the separation of Osthole from the crude extract of Cnidii Fructus was successful . It has been demonstrated that Osthole is active as an anti-trichomonas vaginalis agent. The present investigation is to prepare Cnidii Fructus extract pessaries (suppositories) using both water soluble and insoluble bases as the excipients. The physical properties of the products will be evaluated according to the pharmacopoeial requirements and non-pharmacopoeial requirements will also be determined for academic purposes. The release of the active ingredient , Osthole from various preparations will be determined and the efficacy for anti-trichomonas vaginalis will be studied using a Coulter counter and a flowcytometer as well. 
關鍵字：Cnidii Fructus; Anti-trichomonas; Pessary; Osthole