冬蟲夏草子實體抗單純庖疹病毒第一型活性成份之分離鑑定

陳建志 
國立中國醫
單純庖疹病毒第一型 (Herpes simplex virus type 1; HSV-1) 是屬於庖疹病毒科 (Herpesviridae) 的病毒，根據血清流行病學的調查約有 90% 的人口都曾受過其感染。此病毒感染所造成的臨床症狀為在口部周圍造成潰爛現像，當其在個體造成初次感染 (Primary infection) 後，單純庖疹病毒第一型會於三叉神經結 ( Trigeminal ganglia) 形成潛伏期 (Latent phase)，當個體接受過多紫外線照射、免疫反應降低或者內分泌反應失調，常會造成單純庖疹病毒第一型復發感染 (Recurrent infection)，此種反覆復發的現像常造成個體莫大的困擾，也是現今社會普遍存在之慢性疾病之一，目前在臨床上並無有效治療方法。近年來我們進行抑制單純庖疹病毒第一型之中藥之篩選工作，發現冬蟲夏草子實體 (Cordyceps sinensis) 之甲醇抽取物能有效抑制單純庖疹病毒第一型的複製，其IC50 約為50 mg/ml。由於有如此的初步結果，因? 麂M定配合生物活性追蹤法，進行冬蟲夏草子實體活性成份之分離工作，期望能得到具有強烈活性之化合物，以作為臨床治療及中藥品管之依據。
關鍵字：單純庖疹病毒第一型、潛伏期、復發感染、冬蟲夏草

To identify anti-HSV-1 components from Cordyceps sinensis

Chien-Chih Chen 
National Research Institute of Chinese Medicine
According seroepidemiology study, 90% of human population have been infected by herpes simplex virus type 1 (HSV-1). After primary infection, HSV-1 get into the trigeminal ganglia then set up a latent phase. When individual were in i mmunosuppressed, in much UV-light exposure or in disregulated endocrine secretion, HSV-1 will recovery from trigeminal ganglia, infect target tissues again and cause lesions around lips. The people are suffered from recurrent infection. So far, there is no efficient medicine to treatment this disease. Cordyceps sinensis is a major parasitic fungus on larvae of Lepidoptera. It is one of the well-known fungi used in traditional Chinese medicine. Many fungi belongs to the genus Cordyceps have been demonstr ated to produce natural products with various biological actives. The antiviral and antibacterial functions of Cordyceps sinensis are reported by several investigators. In the present study, we extracted natural products from fruiting bodies of Cordycep s s
關鍵字：Herpes simplex virus type 1, Latent phase, Recurrent infection, Cordyceps sinensis