中藥傳統方劑桃紅四物湯預防缺血性腦中風之療效評估
許準榕
台北醫學大學
腦血管中風是血管性疾病致死及發病的主要原因之ㄧ，影響人類健康甚鉅，相關的缺血性腦中風的病理機轉受到廣泛的研究，但由於其突發性的關係，關於腦血管中風治療藥物的發展，一直沒有很大的進展；而中醫藥傳統方劑在腦血管中風的治療在臨床上使用已久，然而其研究的完善性仍嫌不足，也較不易令人信服。
中醫活血化瘀法作為治療中風病的基本治療在臨床中已廣泛應用，臨床上無論缺血性中風、出血性中風後遺症的病人，活血化瘀法是最常用的治法。中醫傳統活血化瘀方劑中，桃紅四物湯源自醫宗金鑑，由桃仁、紅花、當歸、川芎、赤芍及生地組成，其功效為養血活血，臨床多用於血瘀證的治療，具有極佳的功效，已為中醫臨床廣泛使用的活血化瘀方劑之一。
本實驗室在腦血管中風的研究已相當的完善，關於藥物治療腦血管中風的論文亦發表在國際期刊上，此次計畫預計利用利用大鼠大腦中動脈血管阻塞/再灌流模式評估桃紅四物湯治療缺血性腦中風所造成腦部傷害的效果，並利用西方墨點法及反轉錄-聚合酵素連鎖反應試驗更深入的去觀察桃紅四物湯影響腦部傷害相關因子的表現，以了解桃紅四物湯療效的分子機轉，並且利用螢光染料引發腸繫膜血管血栓之小鼠模式評估桃紅四物湯的抗血栓能力，多方面的去驗證桃紅四物湯在治療腦血管中風方面的療效
關鍵字：缺血性中風、桃紅四物湯、抗血栓
Neuroprotective effects of Tao Hong Si Wu TANG in ischemic cerebral infarction
Joen-Rong Sheu
Taipei medical university
Stroke is a main mortal cause of vascular diseases, and affects healthy critically. Pathological mechanisms of ischemic stroke were studied intensely, but did not have well therapy of ischemic stroke because it is unpredictable. Traditional Chinese medicine formula is used for stoke therapy clinically, but the studies of its effects and mechanisms are still uncompleted and unconvincing.
The Chinese medicine therapy method of promoting blood circulation and removing blood stasis is used in stroke therapy widely. Tao Hong Si Wu TANG of Yizong Jinjian is one of the therapy formulas of promoting blood circulation and removing blood stasis. The components of Tao Hong Si Wu TANG are tao ren, hong hua, dang gui, chuan xiong, chi shao, and sheng di. Tao Hong Si Wu TANG is used in blood stasis syndrome widely; it has blood nourishing effect and also could promote blood circulation.
Our lab establishes completed study in stoke, and publishes several papers at international journal. We will utilize middle cerebral artery occlusion (MCAO) model to estimate the effect of Tao Hong Si Wu TANG on MCAO induced brain injury in rat. Furthermore, we will investigate the molecular mechanisms of Tao Hong Si Wu TANG through western blotting and reverse transcription-polymerse chain reaction (RT-PCR) methods.
關鍵字：stoke, Tao Hong Si Wu TANG, anti-thrombosis
