|
中藥藥膠布及藥酒製劑之成分分析及其釋出效應之研究（3-3）- 中藥藥膠布的藥效動物實驗 陳福安大仁技術學 |
|
| 藥膠布為中藥常用之外用製劑劑型，常用於消腫、消炎及止痛等之醫療用途上。藥膠布的配方與製備方式、指標成份分析、皮膚刺激性、成份的皮膚穿透及藥效評估是確保藥膠布製劑的品質與有效性之重要評估項目。其中成份的皮膚穿透是決定藥膠布藥效之重要關鍵，然而國內中藥藥膠布在成份的皮膚穿透及藥效如止痛、消腫與消炎評估尚待建立之下，建立一套藥膠布成份的皮膚穿透及藥效評估動物模式以確保藥膠布製劑品質與有效性則是當務之急。 本計畫將配合研究重點項目『探討藥膠布中有效成份及其釋出情形之研究』群體計畫建立藥膠布成份的皮膚穿透及藥效評估動物模式以對所製備成的油性及水性藥膠布進行成份皮膚穿透及止痛、消腫與消炎藥效評估，以確保藥膠布製劑品質與有效性，而達到品質管制的目的。 在皮膚穿透動物試驗是使用Franz cell 裝置，以新鮮大白鼠腹部皮膚為穿透障蔽來評估成份之穿透情形。止痛藥效動物試驗則以Writhing test分析動物給藥後抵抗醋酸溶液刺激所引起之疼痛扭曲次數來評估其止痛效果。消腫藥效動物試驗則以Plethysmometer裝置分析Carrageenan 誘導足趾腫脹後之藥膠布消種效果。消炎藥效動物試驗則分析動物給藥後抵抗組織胺誘導微血管通透性之效果來評估其消炎效果。 92年度將評估如意金黃散油性及水性藥膠布的成份皮膚穿透及止痛、消腫與消炎藥效。 |
|
| 關鍵字：藥膠布,皮膚穿透,藥效 |
|
Studies on the component analysis and the effect of release of marker components in plaster formulas and tonic wine formulas.?3-3?- The animal experiment for efficacy of plaster formulas. Fu-An ChenTajen institute of technology |
|
| Plaster is a Chinese medicinal topical preparation, which is frequently used for anti-edema, anti-inflammation and pain-relieving. Formulation and preparation method of plaster, analysis of marker components, skin irritation, skin penetration and efficacy evaluation are important items to ensure the quality and effectiveness of plaster preparations. The skin penetration is critical point to determine efficacy of plaster. However, the methods for evaluation of skin penetration and efficacy such as anti-edema, anti-inflammation and analgesic activity of plaster preparation has not been carried out yet in Taiwan. Therefore, it is necessary to establish a set animal evaluation model of anti-edema, anti-inflammation and analgesic activities to ensure the quality and effectiveness of plaster preparations. To make sure the quality and effectiveness of plaster preparations, the project will establish a set animal model to evaluate anti-edematous, anti-inflammatory and analgesic activities |
|
| 關鍵字：Plaster,Skin penetration,Efficacy |
