小柴胡湯對急性熱中暑大鼠體溫調節作用與相關生理參數變化之影響

闕甫
私立中國醫
小柴胡湯（Xiao-Chai-Hu-Tang; XCHT）出典於傷寒論，由柴胡 (Bupleuri Radix)、黃芩 (Suctellariae Radix）、人參 (Ginseng Radix)、半夏 (Pinelliae Tuber)、炙甘草 (Glycyrrhizae Radix)、生薑 (Zingiberis Rhizoma Recens) 與大棗 (Zizyphi Fructus) 等七味藥物所組成，方中以柴胡為君藥，黃芩為臣藥，配半夏、生薑、人參、草、棗為佐使，主和解少陽，扶正祛邪。中醫臨床上常用來治療發熱、流行性感冒、肺結核、胃炎、肝炎、膽囊炎及腎炎等症。現代藥理學研究顯亦示小柴胡湯具保肝、調節機體免疫機能、抗發炎、鎮靜、抗癲癇、抗腫瘤、抑制胃酸分泌、抗血小板凝集、降血壓及改善血液流變性等作用；此外，小柴胡湯對正常家兔雖不具降溫作用，但對傷寒副傷寒混合菌誘發發熱家兔具明顯之解熱作用。因此，本研究乃利用急性熱中暑大鼠之實驗動物模式，評估小柴胡湯對於急性熱中暑大鼠之血壓、心跳、肛溫及存活時間 (survival time) 等相關生理參數之影響與療效，並進一步測定小柴胡湯對下視丘serotonin與dopamine濃度變化之影響，以及內生性熱原IL-1b 誘發發熱之動物模式之解熱作用，以探討小柴胡湯對急性熱中暑大鼠體溫調節作用之作用機轉。
關鍵字：小柴胡湯，急性熱中暑、體溫調節

Effects of Xiao-Chai-Hu-Tang on the Thermoregulatory and Physiological Parameters During Onset of Acute Heatstroke in Rats

Fu-Yu Chueh
China Medical College
Xiao-Chai-Hu-Tang, was made up of Bupleuri Radix, Suctellariae Radix, Ginseng Radix, Pinelliae Tuber, Glycyrrhizae Radix, Zingiberis Rhizoma Recens and Zizyphi Fructus, was used as a febril prescription by the traditional Chinese physicians. It was firstly described in Shang-Han-Lun, an ancient Chinese medical book, to cure infection-induced fever. It was reported to have sedation, anti-inflammation, anti-tumor, anti-epilepsy, antihypertension, anti-agglutination and antipyretic effects. The purpose of the present study was intended to investigate the thermoregulatory mechanism of Xiao-Chai-Hu-Tang on pyrogenic fever and heat stroke in rats.
關鍵字：Xiao-Chai-Hu-Tang, Acute Heatstroke, Thermoregulatory