癲癇的中西醫學整合研究─ 中藥方TW-001與西藥抗癲癇藥物整合使用的基礎實驗研究(5-3)

蔡景仁
國立成功大
本整合研究在第一、二年的結果，已証實加減柴胡骨牡蠣湯(TW-001)在PTZ及MES誘發癲癇發作模式，具有明顯的抗癲癇效果，及抑制抽搐藥物picrotoxin誘發的癲癇發作。而進一步在細胞內外電氣生理研究亦具有穩定神經細胞體和神經元間傳遞的作用。分析這些結果發現TW-001的抗癲癇作用及機轉與傳統的抗癲癇藥物不盡相同，因而值得進行TW-001與西藥抗癲癇藥物整合使用的基礎實驗研究，經由測量中西抗癲癇藥物整合使用的TD50、ED50和PI來探討兩者在抗癲癇上是否具有”加成作用”、”協同作同”、”降低西藥抗癲癇藥物的副作用”和”降低西藥抗癲癇藥物的使用劑量”等，以評估中、西藥在癲癇的合理整合藥物治療，為未來做TW-001臨床試驗的實驗証據做準備。
關鍵字：癲癇、中國醫學、柴胡龍骨牡蠣湯、合理的多藥治療

The Integration of Chinese and Western Medicine in Epilepsy Research Experimental Studies of the Rational Combination Use of the Chinese Herbal Mixture “Chai-Hu-Long-Ku-Mu-Li-Tan” and Traditional Antiepileptic Drugs(5-3)

Tsai Jing-Jane
Epilepsy research center, Cheng Kung University Hospital
The mixture of “Chai-Hu-Long-Ku-Mu-Li-Tan” (TW-001) described in the Chinese medical book “Shang Han Lun” has the potential antiepileptic effect. According to the guideline of the Anticonvulsant Screening Project (ASP) in U.S.A., we conducted the tests of the antiepileptic properties of TW-001. Tests against convulsions induced by pentylenetetrazol (PTZ) and electroshock showed TW-001 was significantly effective. In addition, TW-001 inhibited significantly the population spikes and field excitatory postsynaptic potentials induced by picrotoxin in rat hippocampal slice when standard extracellular and intracellular field recording techniques were used. Furthermore, different mechanisms of action between TW-001 and traditional antiepileptic drugs were found. Consequently, we want to investigate the efficacy and toxic effects of the combination use of TW-001 and different traditional antiepileptic drugs. All compounds will be compared using dose equivalent based on their respective ED5
關鍵字：Epilepsy, Chai-Hu-Long-Ku-Mu-Li-Tan, Rational polypharmacy