清鼻散(辛夷清肺散合知柏地黃丸)對呼吸道過敏症嗜伊紅性白血球陽離子蛋白之研究

黃秋勇
中國醫藥學
過敏疾病包括過敏性鼻炎、氣喘和異位性皮膚炎為國人常見之疾病，近年來隨著國人生活西方化和工業化，發病率及死亡率有逐年增加的趨勢。本院中西醫合診部和中醫兒科過去的研究顯示過敏病患者在中醫寒熱辨證中顯示有熱證體質者，血清中含有較高的嗜伊紅性白血球及嗜伊紅性白血球陽離子蛋白（Eosinophil cationic protein），而嗜伊紅性白血球陽離子蛋白濃度變化正可顯示嗜伊紅性白血球的活化程度，同時也可反應過敏疾病的嚴重度和預後，亦可作為療效指標；我們過去也使用中藥清鼻散（辛夷清肺散合知柏地黃丸）治療過敏疾病獲得相當好的療效，因此本計劃希望進一步藉現代醫學中臨床試驗的方法驗證清鼻散治療過敏性鼻炎、氣喘的療效，並且研究清鼻散能否調控嗜伊紅性白血球陽離子蛋白的濃度化和其作用機轉。
關鍵字：清鼻散、過敏症、嗜伊紅性白血球陽離子蛋白

Studies of QING BI SAN in the modulation of eosinophil cationic protein

Allergic diseases including allergic rhinitis, asthma, and atopic dermatitis were common in Taiwan. Motality and morbidity of allergic disease increased during past years. Our studies have demonstrated that patients with heat “zheng” had higher serum eosinophil cationic protein (ECP) level, compared to patients with non-heat “zheng”. ECP plays an important role in the diagnosis and treatment of allergic diseases. The changes of ECP level can correlate well with the activation of eosinophils, severity and outcome of disease. In addition, we have treated allergic diseases successfully with QING BI SAN. Now we hope to investigate whether QING BI SAN can modulate the level of ECP. We believe our data will delineate the working mechanisms of QING BI SAN, and improve its applications.
關鍵字：QING BI SAN ，allergic disease，eosinophil cationic protein