歷代玉屏風散對過敏性鼻炎相關因子組織胺、間白素-4與干擾素-γ之研究

何東燦教授
中國醫藥學

現代醫學對過敏性鼻炎有許多的治療方式，而傳統醫學對肺氣虛型過敏性鼻炎患者以玉屏風散治療。歷代玉屏風散組成相同劑量不同比例共四組，為了以現代醫學科技探討玉屏風散對過敏性鼻炎施治的作用機轉，我們首先研究此方劑對於抗過敏作用及調節免疫因子之影響，並研究那一組對於細胞免疫反應正向作用最明顯，以期為臨床應用提供科學數據，且有助於有效成份之分析。因此於中國醫藥學院附設醫院成立〝過敏性鼻炎特別門診〞，篩選36位鼻過敏患者，每名抽取30cc血液加入肝素，針對歷代玉屏風散組之相同(黃耆：白朮：防風)劑量比例不同四組，W組=1:1:1，X組=1:2:1，Y組=6:4:3，Z組=3:1:1，各以五種濃度(5m g/ml、10m g/ml、100m g/ml、250m g/ml、500m g/ml)共20組分別加入剌激物(A23187，PHA)，進行淋巴球分泌間白素-4(Interleukin-4)、干擾素-γ(Interferon-r,IFNr)與中性白血球分泌組織胺(histamine)影響之研究。

期望本實驗能為整合中西醫學建立一可行的研究模式外，並能達成下列之研究目的：
1.闡明中醫方藥(玉屏風散)對過敏性鼻炎施治的作用機轉，並探討其之病因病理。
2.於細胞性免疫反應中，研究玉屏風散在細胞激素網路上所扮演之角色。
3.歷代玉屏風散劑量比例不同共四組，研究那一種組合對過敏性鼻炎具有最佳作用。

關鍵字：玉屏風散、過敏性鼻炎、組織胺、間白素-4、干擾素-γ

Research on the Effects of Various Prescription of Yu Ping Feng San on the Allergic Rhinitis Mediators, Histamine, Interleukin 4 and Interferon-γ

Professor Tung-Tsan, Ho. 
Institute of Chinese Medical Sciences China Medical College
Modern medicine has many methods for treating allergic rhinitis. In traditional Chinese medicine, however, lung-deficiency type allergic rhinitis patients are treated with Yu Ping Feng San. Throughout the years, four different prescriptions of Yu Ping Feng San have been developed, each containing a different proportion of the same ingredients. In order to investigate the mechanisms involved in the treatment of allergic rhinitis with Yu Ping Feng San using modern medical techniques, we first studied the effect Yu Ping Feng San had on the anti-allergy and regulatory factors of the immune system. We also attempted to determine which formula had the greatest positive effect on cellular immunity, to provide a scientific basis for clinical applications and further analysis of the active ingredients. Thus, an “Allergic Rhinitis Special Clinic” was established at the China Medical College Hospital. Thirty-six allergic rhinitis patients selected after screening each gave 30 ml whole blood, to
關鍵字：Yu Ping Feng San, allergic rhinitis, histamine, interleukin-4 (IL-4), interferon-γ.