四磨飲、桂枝茯苓丸、瀉青丸和四逆散對實驗性老鼠急性肝損傷之影響

林國瑞
中國醫藥學
肝病是中國人常見的疾病，其相關病變久為台灣地區十大死亡原因之一。現代醫藥對其並無令人滿意之對策，有待改進。而中醫對此疾病之治療有悠久的歷史與豐富臨床經驗，並且有其獨特多元化的學理思路及相當的療效，給肝病患者提供了很大的希望。

為究明中醫藥之療效與作用機轉，並探討中醫學理之實質，而進行本實驗。本計畫擬以四種中醫方劑 : 四磨飲 ( 理氣 ) 、 桂枝茯苓丸 ( 理血 ) 、 瀉青丸 ( 瀉火 ) 和四逆散( 和解 ) 之水抽出物進行各種保肝模型之試驗。 包括 : 乙醇 ( Alcohol ) 和醋氨酚 ( Acetaminophen )肝毒性物質誘發各種不同急性肝損傷，以期對中醫藥做深入之探討，開發肝病醫療新資源。

第二年將該傳統方劑對實驗性慢性肝損傷(纖維化、肝硬化)等逕行作用探討，其中包括酒精和醋氨酚 ( Acetaminophen )之長期多次投與之損傷模式，以及利用豬血清porcine serum (PC)、二甲基亞硝氨dimethylnitrosamine(DMA)誘發肝纖維化之模式。進而推估四磨飲、桂枝茯苓丸、瀉青丸、四逆散等方藥對此等肝損傷之療效。並對實驗動物進行部分肝切除，以評估方劑對肝臟再生之影響。

第三年擬運用第一、第二年之成果基礎，將此方劑應用於相關病患進行臨床評估及一系列之機轉探討。其中包括對Lipid Peroxidation之影響，Free Radical之清除、SOD之含量、Cytochrome P450 enzyme system之活性…….等等作深入研究。並針對細胞介質( Interleukin-I、Interleukin-II、Interleukin-VI)、45-kD peptide、Type III-procollagen aminoterminal peptide、hyluronic acid、laminin、hepatic hydroxyproline…….等作進一步之研究
關鍵字：肝病、中醫、中醫方劑、急性肝損傷

Effect of Chinese Materia : Syh-Mo-Yiin,Guizhi-Fuling-Wan,Shieh-Qing- Wan and Syh-Nih-Sann on Experimental Acute Liver Damage in Rodents.

Lin Kuo-Juei
Department of Surgery, China Medical College Hospital
As an endemic area of liver diseases in China, the hazard became one of the Ten Leading Causes of Death in Taiwan Area of years. Until recently, it has been accepted that pharmacological treatment of liver disease was difficult. Treatment of patients with liver diseases still remains to be improved. However traditional Chinese Medicine (TCM), with diverse and unique thinking-process, developed through clinical practices and proved to be useful for centuries in the remedy of liver trouble. Interest in TCM on hepatic medications has increased widely in recent years.

Acute liver damages induced by ethanol and acetaminophen in rats were conducted to elucidate the hepatoprotective effects of TCM and study the essence of it. Water extracts of four prescriptions of Chinese Materia Medical: Syn-Mo-Yiin (SMY), Guizhi-Fuling-Wan(GFW), Shieh-Qing-Wan(SQW), and Syh-Nih-Sann(SNS), used in this study, were medicinal herbs and prepared according to different factions of TCM. Their active princ
關鍵字：Disease of the Liver, Traditional Chinese Medicine, Chinese Material, Acute Liver Damage