中樞單胺及類鴉片亞型接受體在不同頻率電針引起鎮痛機轉之研究

蔡輝彥 
中國醫藥學
針刺鎮痛及針刺麻醉的機轉，近幾十年來有許多學者持續地進行研究，而隨著疼痛機轉的不斷瞭解，針刺鎮痛的機轉亦被證實與中樞神經系統中的神經enkephalin、endorphin及單胺類物質5-HT、NE的濃度有關。本研究更進一步以類鴉片亞型接受體作用劑及α-腎上腺素性亞型接受體作用劑和血清張力素性亞型接受體作用劑，利用福馬林試驗來探討針刺鎮痛之機轉。以期瞭解中樞內源性類物質與不同頻率（2Hz、10Hz、100Hz）電針鎮痛機轉的關係。
關鍵字：單胺及類鴉片亞型接受體、不同頻率電針、鎮痛機轉

There are many studies on the mechanism of antinociception of electroacupuncture （EAc）in the past decades. It has been proved that antinociception of EAc was related to the concentration of neuropeptides（enkephalin, endorphin）and monoamines（5HT, NE）. In order to further understand the relationships of EAc analgesia to monoaminergic and opioid subtype receptors in different frequencies, this study will be accomplished by the formalin test in ICR mice.

關鍵字：Studies of Action Mechanisms in Different Frequencies of Electroacupuncture Analgesia on Central Monoaminergic and Opioid Subtype Receptors