抑制陰道滴蟲的中藥成分之篩選與分離〔二〕

蔡(火因)力 
高雄醫學院
Metronidazole是美國FDA所approve之治療藥，目前尚為陰道滴蟲感染之先擇藥物，但由動物實驗得知，此藥對老鼠有致癌作用，使細菌發生病變，及抗藥性之諸多缺點，為長遠打算找尋陰道滴蟲之有效藥則顯得相當有意義。

84年度我們篩選了100種臺灣產植物發現少數幾種之抽取物可以抑制陰道滴蟲之生長，而選擇作用最強之枯里珍配合活性導向分劃法嘗試分離其活性成分，結果由有效之氯仿可溶部分離出一種黃色結晶狀之生物鹼，Ap-1。

今年我們除計畫解決Ap-1之化學構造外並繼續篩選100種台灣產植物，包括與枯里珍同屬之幾種植物。同時另對過去自他種植物所分離的50種生物鹼進行篩選，其目的在找出比metronidazole更有效力，可用于抑制陰道滴蟲生長的化合物，並達到開發台灣產植物之新藥用資源。

關鍵字：陰道滴蟲，枯里珍，生物鹼

Metronidazole was approved as a medicine by FDA in U.S.A. and chosen currently for treating Trichomonas vaginalis. But, metronidazole showed carcinogenicity, in animal experments, mutagen to bacteria and drug-resistance. For the long-term target, searching for other effective drugs against T. vaginalis showed very significant meaning.

We screened 100 species of Formosan Plants and found a few extracts to be inhibitory against the growth T. vaginalis in 1995. We have selected the most strongest one, Antidesma pentadrum var. barbatum, by bioassay-guided fractionaction to isolate the active consituents and obtained an yellowish alkaloid, AP-1; from chloroform-soluble part.

This year, We plan to screen another 100 species of Formosan plants including several species of Antidesma genus and we will screen the isolated 50 alkaloids. Efforts will be also made to elucidate the structure of AP-1 and prepare analogs from it. All these efforts are trying to fine the drugs more effect
關鍵字：Trichomonas vaginalis, Antidesma pentadrum var. barbatum, alkaloid