大爪石斛之抗血小板凝集活性成分之分離

陳建志 
國立中國醫
活血化瘀療法，是我國醫學的一種治療由於血瘀引起的疾病的一種特有療法，近年來已引起國內外醫學界的廣泛重視，施於各種系統的疾病，獲得較好的療效，深入探討活血化瘀療法的實質，應是當前醫藥界重點研究課題之一。

近幾年來我們進行大規模之活血化瘀中藥之篩選工作，發現大爪石斛(Ephemerantha lonchophylla)的乙醇抽出物能強烈抑制因arachidonic acid、collagen及PAF所引起的血小板凝集，其IC50分別為0.02μg/ml，0.07μg/ml，及0.07μg/ml。由於有如此的初步結果，因此決定進行活性成分之找尋工作，期望能找到具強烈活性之化合物，以作為醫療及中藥品管方面之參考。

關鍵字：大爪石斛、抗血小板凝集

Isolation of the antiplatelet principles from Ephemerantha lonchophylla

Thrombosis play an especially important role in the cause of cerebral stroke and cardiac diseases. However, effective antithrombotic drugs still require research and development. "Thrombolytic-vasoactive" Chinese herbs have been used as a treatment in traditional medicine. In recent years, we have studied and isolated some antiplatelet agents from herbal plants. We realized that there are many specific and biologically active substances in natural products to be isolated and developed.

Last year, we screened many Chinese herbs and found a few herbs to have possessed antiplatelet aggergation activity. Among these herbs, the ethanolic extract of the stem of Ephemerantha lonchophylla can strongly inhibit platelet aggregation caused by arachidonic acid, collagen and PAF with an IC50 of 0.02, 0.07, and 0.07μg/mL, respectively. Because of these preliminary results obtained, we have decided to search for the active constitutents contributive to the above mentioned effects with the hop
關鍵字：Ephemerantha lonchophylla, Anti-plantelet aggregation