桔梗、甘草、黃芩、丹參等和抗癌藥的交互作用

朱紫汀
中國醫藥大學
本計畫之方法為以紫杉醇和黃芩，或紫杉醇和甘草、丹參、六味地黃丸等水煮液給予大鼠後，收集不同時點之抽血樣本，以HPLC分析大鼠血中紫杉醇濃度的變化，觀察是否有中西藥交互作用。如觀察到交互作用，將以人類腫瘤細胞株植入裸鼠的皮下，當腫瘤長大至0.5-1公分時，給予紫杉醇和上述中藥水煮液，測量、記錄裸鼠體重和腫瘤大小的變化。
關鍵字：中西藥交互作用；黃芩

Drug interactions of several traditional Chinese medicine and anti-cancer drug

Chu, Zy-Ting
China Medical University
The aim of the project is to use rat and human ttumor-xenografted nude mice as models to evaluate the PK/PD interactions of paclitaxel with Huang Qin (Scutellerie baicalensis Georgi), Dan Shen, or licorice root etc. Such results can provide safety information when any of the above commonly used traditional Chinese medicines is given together with anti-cancer drug, paclitaxel. At the mean time, it is possible to identify some active ingredients from the above Chinese medicines to potentiate the effectiveness of paclitaxel or reduce its effective dose, in order to save the chemotherapy cost, reduce the side effects caused by paclitaxel, and improve the quality of life of cancer patients.
關鍵字：herb-drug interactions；scutellariae baicalein