八段錦對於紅斑狼瘡患者自律神經平衡之臨床療效評估

黃升騰
長庚紀念醫院 高雄院區
本研究的主要目的乃在觀察紅斑性狼瘡(SLE)患者，經八段錦練習後，可否改善自律神經失調，提高副交感神經活性，降低交感神經活性，維持自律神經的平衡。同時檢視SLE患者經功法練習後自律神經的變化，與血中相關生物活性因子(C3、C4、ANA et al)及SLE活動性因子(SLE disease activity index)的相關性，以科學的方法做分析比較。心率變異度為測量交感神經及副交感神經活性的一種靈敏工具，本研究係利用心率變異度，主要是由記錄心電圖，作時域分析與頻域分析,研究交感、副交感神經的交互作用。在本研究的實驗設計上，比較正常人與SLE患者經練習八段錦ㄧ個月後，檢測受試者於於練功前、練功後30分鐘及60分鐘，心率變異度的變化。利用高頻功率、低頻功率、及高低頻功率比，計算出副交感、交感神經的活性及副交感與交感神經的平衡性。因此本研究的重要性乃在於提供八段錦對於紅斑狼瘡患者，臨床輔助治療上醫學參考的依據，及建立有效及安全性管理機制。
關鍵字：紅斑性狼瘡，八段錦，自律神經，心率變異度

Clinical therapeutic evaluation of autonomic nervous balance with practicing Ba Duan Jin in the patients with systemic lupus erythematosus

Sheng-Teng Huang
Chang Gung Memorial Hospital,Kaohsiung
The aim of this study is to investigate the autonomic nervous activity in the patients with systemic lupus erythematosus (SLE) after practicing Ba Duan Jin (BDJ). In the mean time, we also evaluate the relationship between some biological factors such as C3, C4, ANA, SLEDAI and autonomic nervous activity with scientific methodology in the patients with SLE. Heart rate variability (HRV) is a kind of sensitive tool to detect sympathetic and parasympathetic tones. In this study, we will use the EKG to record HRV including the change of time and frequency domains. Based on the changes of time and frequency domain, we can further investigate the interaction of autonomic nervous activity. In our study design, we will compare the HRV in the normal subjects and the patients with SLE after practicing BDJ for at least one month. Then, a resting standard 12-lead EKG will be given to each subject three times, namely, before BDJ exercise and 30 and 60 minutes after the completion of BDJ exercise. High frequency power, low frequency power and low/high ratio will be indicated as the activity of parasympathetic, sympathetic tone and the balance of autonomic nervous activity. Therefore, the importance of this study is to provide the medicinal evidenced base as an adjuvant therapy and establish the effective and safety control system in the patients with SLE who practice BDJ.
關鍵字：systemic lupus erythematosus, Ba Duan Jin, autonomic nervous activity, heart rate variability