Evaluation of the effect of SMD-2 on the human urine trace elements（Cu/Zn and Cu/Se）, quality of life and TCM differentiation of syndrome in head and neck cancer patients receiving the radiotherapy and chemotherapy
China Medical University
Radiotherapy plays an important role in cancer therapy. Most of the early stages of cancer with curative radiotherapy can achieve up to 90% of a 5-year survival rate. Even for patients at late stage, their symptoms also can be relieved. Every radiotherapy and chemotherapy has the potential to cause harm and produce toxicity such as weakness, tired, anorexia nervosa, dry mouth. With the early research, we find that SMD-2 can relieve the symptoms of weakness, tired, anorexia nervosa, dry mouth. Furthermore, we have also found out that the cancer patients who are receiving the therapy of San-Huang-Hsien-Hsin-Tang, shows an inverse ratios between the quality of life and trace elements Cu/Zn and Cu/Se in urine. So we are interested to probe into the mechanism of SMD-2 on this research.
The present study is to evaluate the effects of SMD-2 in the head & neck cancer patients receiving the radiotherapy and chemotherapy, especially examinate their characteristic of TCM constitution, prosecute the TCM differentiation of syndrome, and analyze the distribution of TCM syndrome differentiation in cancer patients. In addition, we are going to assess the clinical evaluation among the ratios of trace elements Cu/Zn and Cu/Se in urine during treatment, and to estimate the quality of life (EORTC: QLQ-C30) during the period of radiotherapy and chemotherapy on the basis of Chinese Medicine Theory.
關鍵字：cancer patients, quality of life, urine, trace element, Cu/Zn and Cu/Se ratios