抗肝纖維化新中草藥方劑之研發

林文川
中國醫藥大學
很多慢性肝炎無論其病因如何，最後會產生肝臟纖維而導致肝硬化。雖然已有很多的努力在尋找有效的抗肝纖維化藥物如S-adenosylmethionine、dilinoleoylphosphatidylcholine及 interferon，但尚未建立有效的治療方法。最近的實驗研究及臨床試驗顯示中藥秘方或草藥萃取物在肝臟纖維化的治療佔重要的角色。本計畫目標是由中草藥研發出新的肝纖維化處方。第一年主要工作是評估種台灣民間藥對thioacetamide誘發鼷鼠肝纖維化的預防效果。第二年是探討30種中草藥對thioacetamide誘發鼷鼠肝纖維化的治療效果。第三年是依據第一、二年的結果設計出5種新的處方，探討這些處方對thioacetamide誘發鼷鼠肝纖維化的預防及治療效果肝。這些成果對肝纖維化新處方的研發有其重要性。
關鍵字：肝纖維化；硫代乙

Development of a new herbal medicinal formula for anti-liver fibrosis

Wen-Chuan Lin
China medical University
Liver fibrosis is the common end stage of most chronic liver disease regardless of the etiology, and its progression leads to cirrhosis. Much effort has been made to search for effective anti-fibrotic remedies, such as S-adenosylmethionine, dilinoleoyl- phosphatidylcholine and interferon. However, there is yet no established therapy for liver fibrosis. Recent experimental studies and clinical trials suggest that Chinese recipes or herbal extracts may play a significant role in the therapy of hepatic fibrosis. This study aimed to develop a new herbal combination for liver fibrosis from plants which were used traditionally by Chinese medicine and Taiwanese？H？Hs herbalists. The major works in the first year are to evaluate the preventive actions of 30 Taiwanese plants on thioacetamide-induced liver fibrosis in mice. In the second year, 30 plants are used to examine the treatment of liver fibrosis induced by thioacetamide in mice. In the third year, 5 new herbal combinations are designed according the results from the results of first and second year. Prevention and treatment of liver fibrosis induced by thioacetamid in mice are examined with these new herbal combination. These results are important in the process for the development of a new herbal combination for liver fibrosis.
關鍵字：liver fibrosis；thioacetamide