川芎茶調散治療偏頭痛之療效評估

陳祈宏
中國醫藥大學附設醫院
偏頭痛是一個很常見的疾患，對於個人、家庭及社會都造成極大之負擔。治療偏頭痛之西藥，大致上分為兩大類：急性之症狀治療與慢性之預防治療。然而目前為止，尚無一個理想有效的治療。可以讓病人滿意而完全脫離偏頭痛的困擾。中醫治療頭痛疾患主要依據辨証論治。古來留傳有很多治療頭痛之方劑，近年來在中國大陸更有諸多這方面的報告。出自宋代太醫局之川芎茶調散於對頭痛之療效令人振奮，但是往往缺乏國際通用之頭痛診斷標準，因此難與西藥作有系統之比較。 本研究預計挑選年滿18歲，小於65歲之偏頭痛患者，治療組及控制組兩組各有50人，隨機分配服用川芎茶調散或安慰劑。以平行、雙盲、對照試驗進行。主要療效指標為急性發作緩解療效與偏頭痛頻次(migraine frequencies)於治療起始點及治療結束時之變化。希望由國際標準之藉入，以西方之科學方法來釐清其於偏頭痛治療之角色。讓偏頭痛之治療多了一個科學治療的新希望。
關鍵字：偏頭痛；川芎茶調散

The Role of Chuan-Chung-Cha-Tiao-San in Migraine Treatment

CHINA MEDICINE UNIVERSITY HOSPITAL
Migraine is a common disorder in daily life. It causes disability and profoundly impairs the quality of life of the sufferers. The treatment of migraine in Western medicine can be divided into abortive and prophylactic. However, there is still no ideal agent till now. There are many strategies for headache treatment in Chinese medicine. Chuan-Chung-Cha-Tiao-San is one of the most popular and proved effective to headache equivalent to migraine. However, the diagnosis was mainly based on traditional theory of medicine. We hope to clarify the exact role of this medicine in migraine diagnosed by worldwide criteria proposed by international headache society. Migraineurs aged 18-65 will be included in our two study groups; the placebo group and the prophylactic group. Fifty subjects are recruited in each group. A randomized, parallel, controlled study will be conducted to evaluate the role of Chuan-Chung-Cha-Tiao-San in migraine treatment.
關鍵字：migraine；Chuan-Chung-Cha-Tiao-San