白朮炮製研究

王靜瓊
臺北醫學大
白朮（Atractylodes macrocephala Koidz.的根莖）為常用補脾健胃中藥材之一，但一般於方劑之中，多用土炒或麩炒白朮，少用生品。因為傳統醫藥典籍記載，土、麩炒白朮可減緩燥性，且可增強補脾健胃之功能、焦白朮可助消化、白朮炭可止血。然而，白朮主成分為精油，其中又以atractylon為主，但其與空氣中的氧作用後，會氧化成atractylenolides II 及III，且atractylenolide III可脫水形成atractylenolide I，因而推測白朮在炮製的過程中，此四個倍半帖成分含量應該會有所改變。另，根據現代藥理研究，亦得知此四個成分分別具有不同藥理活性，因此本研究將自行依古法炮製，並收集產地及台灣北、中、南部市售白朮，以HPLC分析技術檢測其atractylon、atractylenolides I, II, III之含量變化。另外，再利用體內、外制胃酸試驗，觀察土、麩炒後之白朮補脾健胃作用之是否有改變，並利用致突變試驗檢測焦白朮及白朮炭之毒性。綜合炮製後白朮成分變化與制胃酸作用、毒性變化之關係，制定理想的白朮炮製方法及含量規格。
關鍵字：白朮,中藥炮製,制胃酸作用,毒性試驗,指標成分分析

Study on the Processing of Atractylodis Rhizoma

Ching-Chiung Wang
Taipei Medical University
Atractylodis rhizoma (rhizoma of Atractylodes macrocephala Koidz.) is one of the cpmmon tonic Chinese herbs. It has been used to invigorate the spleen and benefit vital energy. However, the processed Atractylodis rhizoma are more popular used than raw material. Because, the processed-Atractylodis rhizoma can enhance the pharmacological functions, the bioactive compounds will be changed. In the present investigation, we will collected three kinds of commercial Atractylodis rhizoma and processed by ourselves. The quantitative analysis of sesquiterpenoids (atractylon, atractylenolids I, II, III) and the metal element analysis were detected by HPLC system in raw, processed and commercial Atractylodis rhizoma. The other hand, the anti-ulcer effects and toxic analysis of Atractylodis rhizoma were evaluated between raw and processed. Principle-activity relationships on anti-ulcer potency of the processed Atractylodis rhizoma will are discussed. In according to the results, we will reg
關鍵字：Atractylodis Rhizoma,he Processing of Chinese herb,Anti-ulcer,Toxicity assay,Bioactive subances analysis