「綠茶提煉物-EGCG」補充治療合併高血脂的第二型糖尿病病人之療效評估

許中華
臺北市立聯合醫院林森（中醫）院區
第二型糖尿病（Type II D.M.），在臨床上頗為常見，因糖尿病及其併發症是造成國人死亡之十大死因之一；因糖尿病而求診另類療法或傳統中醫藥頗為普遍，然而國內相關之研究尚未有較具嚴謹之臨床評估報告。根據美國及一些先進國家所作之研究，65%成年人會尋求另類或補充療法；台大王德榮教授所作之研究，80%曾服用過中藥或草藥以控制血糖。許多動物試驗顯示以EGCG(Epigallocatechin Gallate)為主的綠茶提煉物，具有改善胰島素阻抗性及降低膽固醇及三酸甘油脂。本研究亦計畫藉由雙盲、隨機、對照方式進行初步臨床實驗，來探討綠茶提煉物是否具有治療改善第二型糖尿病人之胰島素阻抗性之療效。此外也要進一步分析綠茶提煉物與相關荷爾蒙及其他因子之關連，以進ㄧ步探討其可能機轉。
關鍵字：高血脂、第二型糖尿病、EGCG、綠茶萃取物

The effect of green tea extract on type 2 diabetes with hyperlipidemia

Hsu Chung-Hua
Taipei City Hospital
Type II diabetes mellitus (Type II DM) is a high prevalence disease in clinics, and its complications are also included in the ten top death causes in Taiwan. It is common for type II DM patients to look for complementary alternative medicine (CAM) and Traditional Chinese Medicine (TCM), which is currently lack of well designed, restricted clinical assessments or evidence. According to previous reports, 65% adults in the U.S.A. would seek for CAM for all kinds of health problems. Further more, Dr. Wang of National Taiwan University revealed that there are 80% of Taiwanese DM patients used TCM drugs or folk herb drugs to control blood sugar level. There were reports of animal studies showed that green tea extract, EGCG (Epigallocatechin Gallate), have effects of lowering cholesterol and triglycerides level and improvement of insulin resistance. The aim of this study is to investigate the therapeutic effects of green tea extract on insulin resistance improvement and related hormone peptides by a double-blinded, randomized and controlled clinical trial.
關鍵字：EGCG, TYPE II DM